Sample preparation for MS
Mass spectrometry is a strong tool for the analysis of organic compounds, determining the molecular mass and chemical structure of the analyte probes. Identifying a protein in proteomic research, detecting genetic targets in genomics or determining pharmacokinetic parameters for drug discovery – the automation of sample preparation increases the throughput and improves the reproducibility for better results.
Identify genetic targets by MALDI
Automated deposition of small volumes onto your sample target removes the bottleneck of manual pipetting.
Standardize your workflow for consistent and reliable results with a BioSpot® automation platform. The calibration of the dispensing unit to a desired target volume forms a homogenous layer of small matrix crystals for the highest resolution of the mass spectra.
Quantitative matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI qMSI) has become a very powerful tool to reveal the spatial distribution of biomolecules and xenobiotics in tissue sections. Especially in pharmaceutical research it is increasingly used for analysis of drug and metabolite distribution as well as in pharmacodynamic biomarker research and toxicology. In this application note we describe how a reliable disposal of standards is achieved by means of the BioSpot® nanoliter liquid handling workstation.
We are thankful to our colleagues at NUVISAN for sharing these data and the collaboration to establish automated solutions for the qMSI workflow!