Microneedle coating and production

The delivery of biomolecules via the transdermal route by microneedle patches provides several advantages in both, drug action and patient comfort. Applying drugs or vaccines to the skin requires a reproducible and safe loading of each microneedle arrayed on a tiny patch, making a precise dispensing technology absolutely essential.

Single droplet dispensing

Non-contact, piezoelectric dispensing of nanoliter droplet volumes on microneedle structures

With BioFluidix' dispensing technology, your possibilities of reproducible dispensing on microneedles are infinite. Carefully control the droplet volume, velocity and frequency of the ejected droplet for an accurate and rapid coating of microneedle patches. Overcome the major drawbacks of material waste, formulation reuse and the limitations of formulation viscosity by non-contact droplet delivery.

Set the right dispensing parameters

Get the right volume, frequency and droplet velocity for each formulation to be deposited on microneedles.

Enhance the dispensing performance with the SmartDrop System and calibrate your drug formulations to a specific droplet volume, adjust the droplet velocity to enhance the hit rate or change the droplet frequency to have full control of your dispensing process.

Target detection

Vision-based detection of the individual microneedle tips by the TopView Camera

  • Automated patch geometry detection by TopView camera
  • Automated microneedle position detection
  • Hit-rate and droplet verification

Application Note

Microneedle (MN) patches are the innovative and minimaly invasive transdermal drug delivery system of the future. These patches consist of multiple tiny needles measuring around 0.5 mm in height arrayed with a pitch smaller than 1 mm. In contrast to common hypodermic needle-based drug deliveries, these patches are applied to penetrate the outermost skin layer (stratum corneum) and only deliver large biomolecules, such as drugs or vaccines into the viable epidermis.

Read how the BioSpot workstation is applied to realize fully automated workflows for the relaible and precise drug load on the individual microneedles!