Innovation & Research
The participation in publicly funded research projects allows us to contribute to the investigation and development of novel technological approaches to deliver small volumes of liquids of any kind and any rheology. Our scientific background in combination with our engineering expertise result in precise and reliable solutions, driving the low volume dispensing market to unprecedented possibilities.
KikA-IPK
KI-Kognitionsunterstützendes Assistenzsystem zur InProzessKontrolle in der Fertigung
Project description
The KIkA-IPK project is a collaboration project that aims to develop a cognitive AI Cloud (KIC) platform for scalable KIC-services that can provide individualized real-time in-process-control for a variety of manufacturing processes. The micro liquid dispensing process based on the PipeJet® technology of the BioFluidix GmbH is a production process that can be optically monitored and is therefore suitable for a real-time in-process-control. Within the KIkA-IPK project, the AI based KIC platform is used to develop a novel approach to control the micro liquid dispense process during calibration and production, with the goal to improve the volume detection and dispensing accuracy and the calibration efficiency, as well as achieving a failure forecasting and liquid class detection method.
Project duration
01.11.2021 - 31.10.2024
Project partners Gefertec, Relimetrics, DiHeSys, PSI, Gestalt Robotics, TU Berlin
Funding program
Bundesministerium für Bildung und Forschung
Promotor
PTKA - Projektträger Karlsruhe
ASTANA
Combined identification and quantitative antibiotic resistance testing of bacteria using digital shearography for faster and more selective treatment of sepsis patients.
Project description
Within the ASTANA project, a faster and more targeted treatment of sepsis patients is sought through improved diagnostics, by using accelerated and combined pathogen identification and quantitative antibiotic resistance testing. The typification takes place via polymerase chain reaction. When determining the antibiotic susceptibility, optical methods such as shearography and quantitative phase reconstruction are used to evaluate centrifugal microfluidics. Efficient image recognition algorithms are used to quantify the number of pathogens and extrapolate the pathogen growth through repetition during the incubation phase, thereby gaining important diagnostic time. The sub-project of BioFluidix GmbH includes the product development of a functional demonstrator for the accelerated antibiotic susceptibility testing, which includes the automation of the centrifugal microfluidics and its temperature control for incubation, as well as the integration of the optical system and its high-precision positioning.
Project duration
01.08.2022 - 31.07.2025
Project partners Spindiag, Hahn-Schickard, ILM Ulm, Universitätsklinikum Ulm, ImFusion
Funding program
Bundesministerium für Bildung und Forschung
Promotor
VDI
FREEDOM
Frequency Domain Multichannel Deconvolution for Marker Discrimination - Platform for digital multiplexed assays.
Project description
BioFluidix coordinates the project ensuring a successful transformation from concept to an innovative platform for digital multiplex assays. The platform consists of a centrifugal microfluidic PCR device, a microfluidic chip for emulsifying a reaction mix and a readout device to be developed with a high degree of multiplexing. The device help to examine samples for the presence of specific DNA sequences much faster, more easily and with greater complexity. For example, blood samples could be tested for the presence of cancer DNA or food samples such as corn for the presence of genetically manipulated components (GMOs) in the application.
BioFluidix part is the development and implementation of a concept that combines the individual project results of the different partners into a compact analysis device.
Project duration
01.02.2021 - 31.01.2024
Project partners
Hahn-Schickard, Cadida Software, BIOTECON Diagnostics, ILM Ulm
Funding program
Bundesministerium für Bildung und Forschung
Promotor
VDI Technologiezentrum
3D-Bio-Net
The 3D Bio-Net is a collaboration project to establish an advanced 3D Bio-Printing platform in the network of small and medium-sized enterprises (KMU).
As part of the overall project, Biofluidix is engaged in the research of dosing technologies for 3D bio-printing and the realization of a 3D-BioPrinter with sterilizable dosing components. The aim of the sub-project is to provide a device that is equipped with innovative, sterilizable dosing technology based on disposable components and can be used for the research work of the partners. At the end of the project, a functional, experimentally characterized demonstrator with associated 3D bio-printing processes will be presented to the public.
3D-TuMo Print
Bio-printable 3D in vitro tumor-tissue-model for high throughput testing of tumor therapeutics.
Project description
The number of cancer patients is increasing steadily. This fact expresses the urgent need of understanding the origin of tumors and drives the development of novel treatment methods. Since the development of new tumor-therapeutic substances is highly time-consuming and costly, an affordable alternative is desired for the future. This can be achieved by earlier identification of relevant drug candidates and better prediction of their efficacy. Therefore, it is necessary to use a suitable in vitro substitute, like a 3D-tumor-tissue model, for an early testing. The aim of the project 3D TuMoPrint is to establish a high-throughput testing system for tumor therapeutics based on a 3D-organotypic-tumor-tissue model in biomimetic hydrogels for the production in a bio-printer workstation. Apart from the model production, the system should have an integrated microscopic control to simplify the analysis of the models.
Project duration
15.01.2019 - 15.01.2021
Project partners
HFU, Campus Schwenningen, Pelobiotech GmbH
Funding program
Baden Württemberg - Ministerium für Wissenschaft Forschung und Kunst
dINA
Digital immuno-isothermal nucleic acid amplification (dINA) assay for high-sensitivity analyzes with a wide dynamic range.
The goal is to use the dINA project to replace existing technologies (ELISA etc.) for the precise quantification of active substances and to establish a new technology platform for highly sensitive analytical methods. Compared to existing methods, it represents a significant system simplification exceeding the current state of the art technologies in terms of precision of quantification as well as speed and cost-effectiveness. Therefore, the aim of this project is to realize and characterize a functional model of a centrifugal processing device, which is suitable for the automated performance of biochemical analyzes based on so-called "digital amplification processes" in emulsion.